Open AccessFrequent expression of activation-induced cytidine deaminase in diffuse large B-cell lymphoma tissues from persons living with HIV
Author(s) -
Volodymyr Shponka,
Candace Y. Reveles,
Sinthia Alam,
Melba C. Jaramillo,
Alanna Maguire,
Lisa M. Rimsza,
Samantha Kendrick
Publication year - 2020
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002653
Subject(s) - diffuse large b cell lymphoma , cytidine deaminase , lymphoma , immunosuppression , immunology , medicine , cancer research , biology , antibody
The increased risk for persons living with HIV to develop diffuse large B-cell lymphoma (DLBCL) even in the post-antiretroviral therapy eras suggests a role beyond immunosuppression in lymphoma development. However, the mechanisms leading to lymphoma in the HIV setting are not fully understood. HIV is known to induce activation-induced cytidine deaminase (AID) levels in nonneoplastic B cells in vitro and chronic AID expression may play an important role in lymphomagenesis. Although AID expression is observed in B-cell lymphoma, studies in HIV-associated DLBCL are limited.