Open AccessInflammation, cytomegalovirus and the growth hormone axis in HIV-exposed uninfected Zimbabwean infants
Author(s) -
Ceri Evans,
Bernard Chasekwa,
Sandra Rukobo,
Margaret Govha,
Kuda Mutasa,
Robert Ntozini,
Jean H. Humphrey,
Andrew J. Prendergast
Publication year - 2020
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002646
Subject(s) - medicine , growth factor , insulin like growth factor , human immunodeficiency virus (hiv) , logistic regression , immunology , inflammation , cytomegalovirus , physiology , endocrinology , viral disease , receptor , herpesviridae
Despite avoiding HIV infection, HIV-exposed uninfected (HEU) infants have poorer clinical outcomes than HIV-unexposed infants, including impaired growth. The growth hormone (GH) axis is an important regulator of infant growth through hepatic synthesis of insulin-like growth-factor-1 (IGF-1), and may be disrupted by chronic inflammation and acute infections, including cytomegalovirus (CMV). We tested the hypothesis that these factors lead to disruption of the GH axis in HEU infants, which might contribute to their impaired growth.