Open AccessHIV-1 induced changes in HLA-C∗03 : 04-presented peptide repertoires lead to reduced engagement of inhibitory natural killer cell receptors
Author(s) -
Maja Ziegler,
Annika Nelde,
Jeffrey K. Weber,
Christian M Schreitmüller,
Glòria Martrus,
Tien Huynh,
Madeleine J. Bunders,
Sebastian Lunemann,
Stefan Stevanović,
Ruhong Zhou,
Marcus Altfeld
Publication year - 2020
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002596
Subject(s) - human leukocyte antigen , inhibitory postsynaptic potential , receptor , human immunodeficiency virus (hiv) , immunology , peptide , virology , lead (geology) , cell , biology , antigen , biochemistry , neuroscience , paleontology
Viral infections influence intracellular peptide repertoires available for presentation by HLA-I. Alterations in HLA-I/peptide complexes can modulate binding of killer immunoglobuline-like receptors (KIRs) and thereby the function of natural killer (NK) cells. Although multiple studies have provided evidence that HLA-I/KIR interactions play a role in HIV-1 disease progression, the consequence of HIV-1 infection for HLA-I/KIR interactions remain largely unknown.