Open AccessChanges in gastrointestinal microbial communities influence HIV-specific CD8+ T-cell responsiveness to immune checkpoint blockade
Author(s) -
Ivo N. SahBandar,
Glen M. Chew,
Michael J. Corley,
Alina P.S. Pang,
Naoky Tsai,
Nancy Hanks,
Vedbar S. Khadka,
Nichole R. Klatt,
Tiffany HensleyMcBain,
Ma Somsouk,
Ivan Vujkovic-Cvijin,
Dominic Chow,
Cecilia Shikuma,
Lishomwa C. Ndhlovu
Publication year - 2020
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002557
Subject(s) - tigit , fusobacteria , immunology , immune system , biology , cd8 , t cell , gut flora , bacteroidetes , genetics , 16s ribosomal rna , bacteria
The aim of this study was to examine the relationship between gut microbial communities in HIV-infected individuals on suppressive antiretroviral therapy (cART), and the peripheral HIV-Gag-specific CD8 T-cell responses before and after ex-vivo immune checkpoint blockade (ICB).