Open AccessCD300a identifies a CD4+ memory T cell subset with a higher susceptibility to HIV-1 infection
Author(s) -
Joana Vitallé,
Laura Tarancón-Díez,
María Reyes Jiménez-León,
Íñigo Terrén,
Ane Orrantia,
Cristina Roca-Oporto,
Luis F. LópezCortés,
Ezequiel RuizMateos,
Olatz Zenarruzabeitia,
Francisco Borrego
Publication year - 2020
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002544
Subject(s) - dengue fever , virology , immunology , human immunodeficiency virus (hiv) , biology , in vitro , immunopathology , genetics
: Human CD300a is known to promote the infection by dengue and other enveloped viruses and is overexpressed on CD4 T cells from HIV-1-infected patients. We found that infected CD4+RA- T cells from untreated HIV-1-infected patients were mostly CD300a+. Furthermore, CD300a expressing CD4+RA- T cells from healthy donors were significantly more infected by HIV-1 in vitro than CD300a- cells. CD300a might represent a biomarker of susceptibility to HIV-1 infection on memory CD4 T lymphocytes.