Open AccessGenetic variations in the host dependency factors ALCAM and TPST2 impact HIV-1 disease progression
Author(s) -
Zita Kruize,
Irma Maurer,
Brigitte BoeserNunnink,
Thijs Booiman,
Neeltje A. Kootstra
Publication year - 2020
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002540
Subject(s) - alcam , single nucleotide polymorphism , biology , pathogenesis , immunology , allele , disease , multicenter aids cohort study , genetics , genotype , gene , medicine , viral disease , human immunodeficiency virus (hiv) , sida , cell adhesion molecule
Recently, the activated leukocyte cell adhesion molecule (ALCAM) and tyrosylprotein sulfotransferase 2 (TPST2) have been identified as important host dependency factors (HDFs) for in-vitro HIV-1 replication. To determine whether these genes play a role in HIV-1 pathogenesis, we analysed whether naturally occurring genetic variations were associated with the clinical course of infection.