Open AccessGenetically-edited induced pluripotent stem cells derived from HIV-1-infected patients on therapy can give rise to immune cells resistant to HIV-1 infection
Author(s) -
Fernando Teque,
Yi Lin,
Fei Xie,
Jiaming Wang,
Maelig Morvan,
Yuet Wai Kan,
Jay A. Levy
Publication year - 2020
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002539
Subject(s) - induced pluripotent stem cell , biology , immune system , peripheral blood mononuclear cell , cxcr4 , virology , genetic enhancement , stem cell , immunology , in vitro , gene , microbiology and biotechnology , chemokine , embryonic stem cell , genetics
To assess the in-vitro CCR5---tropic and CXCR4---tropic HIV---1 infectivity of immune cells, particularly macrophages, derived from CCR5 gene---edited induced pluripotent stem cells (iPSCs) obtained from the peripheral blood mononuclear cells (PBMC) of HIV---infected patients on antiretroviral therapy (ART).