Open AccessMonocyte and CD4+ T-cell antiviral and innate responses associated with HIV-1 inflammation and cognitive impairment
Author(s) -
Vishakha Sharma,
Christopher Bryant,
María Montero,
Matthew Creegan,
Bonnie M. Slike,
Shelly J. Krebs,
Silvia RattoKim,
Victor Valcour,
Pasiri Sithinamsuwan,
Thep Chalermchai,
Michael A. Eller,
Diane L. Bolton,
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Publication year - 2020
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002537
Subject(s) - immunology , inflammation , immune system , monocyte , t cell , biology , proinflammatory cytokine , cd14 , flow cytometry , medicine
Mechanisms underlying immune activation and HIV-associated neurocognitive disorders (HAND) in untreated chronic infection remain unclear. The objective of this study was to identify phenotypic and transcriptional changes in blood monocytes and CD4 T cells in HIV-1-infected and uninfected individuals and elucidate processes associated with neurocognitive impairment.