Open AccessProductive HIV infection in astrocytes can be established via a nonclassical mechanism
Author(s) -
Guanhan Li,
Dragan Maric,
Eugene O. Major,
Avindra Nath
Publication year - 2020
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002512
Subject(s) - biology , virology , endocytosis , transfection , cell culture , virus , cell , transduction (biophysics) , viral entry , gp41 , cell fusion , antibody , immunology , viral replication , epitope , biochemistry , genetics
Astrocytes are proposed to be a critical reservoir of HIV in the brain. However, HIV infection of astrocytes is inefficient in vitro except for cell-to-cell transmission from HIV-infected cells. Here, we explore mechanisms by which cell-free HIV bypasses entry and postentry barriers leading to a productive infection.