Open AccessMapping the extent of heterogeneity of human CCR5+ CD4+ T cells in peripheral blood and lymph nodes
Author(s) -
John Zaunders,
C. Mee Ling Munier,
Helen M. McGuire,
Hannah Law,
Annett Howe,
Yin Xu,
Barbara Fazekas de St Groth,
Peter Schofield,
Daniel Christ,
Brad Milner,
Solange Obeid,
Wayne B. Dyer,
Nitin K. Saksena,
Anthony D. Kelleher
Publication year - 2020
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002503
Subject(s) - cytotoxic t cell , cxcr3 , immunology , granzyme b , lymph node , c c chemokine receptor type 6 , population , biology , lymph , immunophenotyping , granzyme a , t cell , il 2 receptor , interleukin 21 , granzyme , flow cytometry , chemokine receptor , antigen , cd8 , medicine , immune system , pathology , chemokine , perforin , in vitro , biochemistry , environmental health
CD4 T cells that express the chemokine receptor, CCR5, are the most important target of HIV-1 infection, but their functions, phenotypes and anatomical locations are poorly understood. We aimed to use multiparameter flow cytometry to better define the full breadth of these cells.