Open AccessTIGIT is upregulated by HIV-1 infection and marks a highly functional adaptive and mature subset of natural killer cells
Author(s) -
Elena Vendrame,
Christof Seiler,
Thanmayi Ranganath,
Nancy Q. Zhao,
Rosemary Vergara,
Michel Alary,
AnnieClaude Labbé,
Fernand Guédou,
Johanne Poudrier,
Susan Holmes,
Michel Roger,
Catherine A. Blish
Publication year - 2020
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002488
Subject(s) - tigit , immunology , biology , cytotoxic t cell , population , natural killer cell , downregulation and upregulation , cancer research , immune system , cd8 , microbiology and biotechnology , medicine , in vitro , biochemistry , environmental health , gene
Our objective was to investigate the mechanisms that govern natural killer (NK)-cell responses to HIV, with a focus on specific receptor--ligand interactions involved in HIV recognition by NK cells.