Open AccessPlasma nucleotide reverse transcriptase inhibitor concentration and their associations with liver and renal parameters in people living with HIV
Author(s) -
Xinzhu Wang,
Marta Boffito,
Laura Dickinson,
Emmanouil Bagkeris,
Saye Khoo,
Frank A. Post,
Jaime Vera,
Ian Williams,
Amalia Ndoutoumou,
Jane Anderson,
Patrick Mallon,
Myra O. McClure,
Alan Winston,
Caroline Sabin,
Poppy Study
Publication year - 2020
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002479
Subject(s) - emtricitabine , abacavir , lamivudine , reverse transcriptase inhibitor , reverse transcriptase , renal function , tenofovir , virology , medicine , biology , pharmacology , human immunodeficiency virus (hiv) , hepatitis b virus , viral load , genetics , virus , antiretroviral therapy , polymerase chain reaction , gene
: Associations between markers of liver and renal dysfunction and nucleotide reverse transcriptase inhibitor plasma exposure are ill-defined. As part of a large cohort study (Pharmacokinetic and Clinical Observations in People over Fifty), we analysed associations between alanine aminotransferase and estimated glomerular filtration rate results in people living with HIV on tenofovir disoproxil fumarate, emtricitabine, abacavir and lamivudine. While we found no associations between nucleotide reverse transcriptase inhibitor concentrations and alanine aminotransferase, lower estimated glomerular filtration rate values were associated with greater tenofovir, emtricitabine and lamivudine exposure, whereas abacavir showed no associations.