Open AccessImmune effects of Lactobacillus casei Shirota in treated HIV-infected patients with poor CD4+ T-cell recovery
Author(s) -
Simone de Barros Tenore,
Vivian Iida AvelinoSilva,
Priscilla R. Costa,
Lucas M Franco,
Éster Cerdeira Sabino,
Jorge Kalil,
Natalia B Cerqueira,
Zelinda Nakagawa,
Esper G. Kallás
Publication year - 2020
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002420
Subject(s) - interquartile range , medicine , placebo , gastroenterology , cd8 , lactobacillus casei , immune system , immunology , t cell , viral load , human immunodeficiency virus (hiv) , biology , pathology , alternative medicine , food science , fermentation
HIV infection leads to depletion of intestinal CD4+ T cells, mucosal barrier dysfunction, increased gut permeability and microbial translocation even among patients on suppressive ART. Previous studies suggest probiotics may help restore intestinal function.