Open AccessT cells with high PD-1 expression are associated with lower HIV-specific immune responses despite long-term antiretroviral therapy
Author(s) -
Bernard Macatangay,
Rajesh T. Gandhi,
R. Brad Jones,
Deborah McMahon,
Christina M. Lalama,
Ronald J. Bosch,
Joshua C. Cyktor,
Abu Thomas,
Luann Borowski,
Sharon A. Riddler,
Evelyn Hogg,
Eva M. Stevenson,
Joseph J. Eron,
John W. Mellors,
Charles R. Rinaldo
Publication year - 2020
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002406
Subject(s) - viremia , cd8 , immune system , immunology , t cell , flow cytometry , medicine , antiretroviral therapy , viral load , biology , virology , human immunodeficiency virus (hiv)
We evaluated frequencies of T cells with high PD-1 expression (PD-1) before and after long-term effective antiretroviral therapy (ART), and determined if frequencies on-ART correlated positively with measures of HIV persistence and negatively with HIV-specific responses.