Open AccessPlasma inflammatory biomarkers link to diffusion tensor imaging metrics in virally suppressed HIV-infected individuals
Author(s) -
Kevin Chang,
Thomas A. Premeaux,
Yann Cobigo,
Benedetta Milanini,
Joanna Hellmuth,
Leah H. Rubin,
Shireen Javandel,
Isabel Elaine Allen,
Lishomwa C. Ndhlovu,
Robert Paul,
Victor Valcour
Publication year - 2020
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002404
Subject(s) - fractional anisotropy , diffusion mri , white matter , corpus callosum , neopterin , medicine , superior longitudinal fasciculus , biomarker , population , pathology , magnetic resonance imaging , biology , radiology , biochemistry , environmental health
Inflammation may contribute to brain white matter health in people living with HIV who report cognitive symptoms despite adherence to combination antiretroviral therapy and viral suppression. We explored relationships between diffusion tensor imaging (DTI) metrics of white matter, plasma biomarkers of immune activation, and cognitive function in the HIV-infected population.