Open AccessCD4+ cell count stratification to guide tuberculosis preventive therapy for people living with HIV
Author(s) -
Lelia H. Chaisson,
Valéria Saraceni,
Sylvia Cohn,
Dena Seabrook,
Solange Cavalcante,
Richard E. Chaisson,
Jonathan E. Golub,
Betina Durovni
Publication year - 2020
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002398
Subject(s) - medicine , tuberculosis , isoniazid , incidence (geometry) , antiretroviral therapy , tuberculin , mortality rate , human immunodeficiency virus (hiv) , immunology , pediatrics , viral load , pathology , physics , optics
In 2018, Brazilian guidelines changed to recommend tuberculosis (TB) preventive therapy for all people with HIV and a CD4 cell count 350 cells/μl or less, but only for those with a positive tuberculin skin test (TST) if CD4 cell count is than 350 cells/μl. We determined the potential effectiveness of CD4-based guidelines for TB testing and preventive therapy.