Open AccessImaging correlates of the blood–brain barrier disruption in HIV-associated neurocognitive disorder and therapeutic implications
Author(s) -
Joga Chaganti,
Karthik Marripudi,
Lukas P. Staub,
Caroline Rae,
Thomas M. Gates,
Kirsten Moffat,
Bruce J. Brew
Publication year - 2019
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002300
Subject(s) - blood–brain barrier , context (archaeology) , neuroinflammation , cerebrospinal fluid , medicine , magnetic resonance imaging , white matter , inflammation , pathology , immunology , central nervous system , biology , paleontology , radiology
HIV-associated neurocognitive disorders (HANDs) in the context of suppressive combination antiretroviral therapy (cART) still occur. We explored the role of blood-brain barrier (BBB) disruption in the pathogenesis of HAND in the context of fully suppressive cART using dynamic contrast enhanced perfusion (DCE-P) MRI. DCE-P is a new MRI technique that measures capillary permeability as an indicator for BBB integrity. We hypothesized that virally suppressed incident HAND would be associated with an impaired BBB as determined by DCE-P.