Open AccessLack of HIV-1 integrase inhibitor resistance among 392 antiretroviral-naïve individuals in a tertiary care hospital in Beijing, China
Author(s) -
Lifeng Liu,
Lili Dai,
Jun Yao,
Pinliang Pan,
Li Li,
Zhiying Liu,
Xizhao An,
Lijun Sun,
Hao Wu,
Bin Su,
Tong Zhang
Publication year - 2019
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002282
Subject(s) - beijing , integrase , china , integrase inhibitor , human immunodeficiency virus (hiv) , virology , medicine , lentivirus , antiretroviral therapy , viral disease , viral load , geography , archaeology
: Reports of resistance to integrase strand transfer inhibitors (INSTIs) are now not uncommon. We analyzed the HIV int gene from plasma of antiretroviral-naïve individuals during acute and chronic HIV-1 infection. No individual with major INSTI mutations was identified. Two individuals harbored INSTI accessory mutations E157Q/T97A were detected for the first time. Our results emphasize the need to consider testing for INSTI resistance at baseline as this class of drugs is increasingly used in clinical routine.