Open AccessSuboptimal stimulation by weak agonist epitope variants does not drive dysfunction of HIV-1-specific cytotoxic T lymphocyte clones
Author(s) -
Mark Alexander Grossman,
Christian Hofmann,
Hwee Ng,
Otto O. Yang
Publication year - 2019
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002259
Subject(s) - epitope , ctl* , cytotoxic t cell , biology , immunology , cd8 , virology , immune system , antigen , genetics , in vitro
To assess whether weakly recognized epitope variants induce anergy in HIV-1-specific CD8 T lymphocyte (CTL) clones as a mechanism of dysfunction.