Open AccessDefining cerebrospinal fluid HIV RNA escape
Author(s) -
Alan Winston,
Andrea Antinori,
Paola Cinque,
Howard S. Fox,
Magnus Gisslén,
Timothy J. Henrich,
Scott Letendre,
Deborah Persaud,
Richard W. Price,
Serena Spudich
Publication year - 2019
Publication title -
aids
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002252
Subject(s) - cerebrospinal fluid , rna , human immunodeficiency virus (hiv) , lentivirus , antiretroviral therapy , virology , medicine , immunology , viral disease , biology , viral load , pathology , genetics , gene
: Suppression of plasma HIV RNA is most often attainable with effective antiretroviral therapy. Despite this, in some individuals, detection of HIV RNA remains evident in the cerebrospinal fluid (CSF) which is generally termed CSF HIV RNA escape. Defining CSF HIV RNA escape from a virological point of view, a symptomatology point of view and its management has many challenges with several different definitions being utilized. In this editorial, we outline proposed consensus definitions of CSF HIV RNA escape with consideration of virological, symptomatology and management aspects of this condition.