Open AccessThe impact of HIV central nervous system persistence on pathogenesis
Author(s) -
Bruce J. Brew,
Stephanie L. Barnes
Publication year - 2019
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002251
Subject(s) - pathogenesis , persistence (discontinuity) , central nervous system , human immunodeficiency virus (hiv) , immunology , medicine , biology , virology , neuroscience , geotechnical engineering , engineering
: The persistence of HIV in the central nervous system is somewhat controversial particularly in the context of HIV viral suppression from combined antiretroviral therapy. Further, its significance in relation to HIV pathogenesis in the context of HIV-associated neurocognitive disorders, systemic HIV pathogenesis, and eradication in general, but especially from the brain, are even more contentious. This review will discuss each of these aspects in detail, highlighting new data, particularly from recent conference presentations.