Open AccessDifferences in the rate of nicotine metabolism among smokers with and without HIV
Author(s) -
Rebecca L. Ashare,
Morgan Thompson,
Frank T. Leone,
David Metzger,
Robert Gross,
Karam Mounzer,
Rachel F. Tyndale,
Caryn Lerman,
Martin C. Mahoney,
Paul M. Cinciripini,
Tony P. George,
Ronald G. Collman,
Robert A. Schnoll
Publication year - 2019
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002127
Subject(s) - cotinine , nicotine , cyp2a6 , medicine , smoking cessation , human immunodeficiency virus (hiv) , metabolite , population , quartile , physiology , immunology , metabolism , confidence interval , pathology , environmental health , cytochrome p450 , cyp1a2
HIV-infected smokers lose more life years to tobacco use than to HIV infection. The nicotine metabolite ratio (NMR), a biomarker of CYP2A6, represents individual variation in the rate at which nicotine is metabolized and is associated with response to smoking cessation treatments. We evaluated whether HIV-infected smokers metabolize nicotine faster than HIV-uninfected smokers, which may contribute to the disproportionate smoking burden and may have important treatment implications.