Open AccessA high mucosal blocking score is associated with HIV protection
Author(s) -
Alexandre Girard,
Norma Rallón,
José M. Benito,
Fabienne Jospin,
Carmen Rodríguez,
Blandine Chanut,
Fahd Benjelloun,
Jorge del Romero,
Bernard Verrier,
F. Lucht,
Jean Jacques Pin,
Christian Genin,
Mara Biasin,
Mario Clerici,
Stéphane Paul
Publication year - 2019
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002099
Subject(s) - langerin , antibody , dc sign , receptor , sign (mathematics) , immunology , blocking (statistics) , human immunodeficiency virus (hiv) , antigen , biology , virology , dendritic cell , medicine , computer science , mathematical analysis , computer network , mathematics
Early steps of HIV infection are mediated by the binding of the envelope to mucosal receptors as α4β7 and the C-type lectins DC-SIGN and langerin. Previously Env-specific B-cell responses have been reported in highly exposed seronegative individuals (HESN).