Open AccessCerebrospinal fluid viral escape in aviremic HIV-infected patients receiving antiretroviral therapy
Author(s) -
Ignacio PérezValero,
Ronald J. Ellis,
Robert K. Heaton,
Reena Deutsch,
Donald Franklin,
David B. Clifford,
Ann C. Collier,
Benjamin B. Gelman,
Christina M. Marra,
J. Allen McCutchan,
Allison Navis,
Ned Sacktor,
David M. Simpson,
Igor Grant,
Scott Letendre
Publication year - 2019
Publication title -
aids
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002074
Subject(s) - medicine , cerebrospinal fluid , viral load , ritonavir , interquartile range , atazanavir , odds ratio , pleocytosis , viral meningitis , antiretroviral therapy , gastroenterology , protease inhibitor (pharmacology) , immunology , human immunodeficiency virus (hiv) , bacterial meningitis
During antiretroviral therapy, HIV RNA can be detected in cerebrospinal fluid (CSF) when it is undetectable in plasma, a condition termed 'CSF viral escape'. The aim of the current study was to determine the prevalence and risk factors for CSF viral escape in two large cohorts in the USA.