Open AccessIn-vitro viral suppressive capacity correlates with immune checkpoint marker expression on peripheral CD8+ T cells in treated HIV-positive patients
Author(s) -
Pieter Pannus,
Philipp Adams,
Elisabeth Willems,
Leo Heyndríckx,
Éric Florence,
Sofie Rutsaert,
Ward De Spiegelaere,
Linos Vandekerckhove,
Carole Seguin-Devaux,
Guido Vanham
Publication year - 2019
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002068
Subject(s) - biology , cytotoxic t cell , cd8 , immune system , immunology , cytokine , t cell , viral load , virology , virus , in vitro , biochemistry
To determine whether viral suppressive capacity (VSC) of CD8+ T cells can be boosted by stimulation with HIV-1 peptides and whether the ability to control HIV-1 replication correlates with immunological (cytokine production and CD8+ T-cell phenotype) and viral reservoir measures (total HIV-1 DNA and cell-associated RNA) in well treated HIV-infected chronic progressors.