Open AccessB7-H6-mediated downregulation of NKp30 in natural killer cells contributes to HIV-2 immune escape
Author(s) -
Olivier Lucar,
Mamadou H. Diallo,
Charles Bayard,
Assia Samri,
Nadine Tarantino,
Patrice Debré,
Rodolphe Thiébaut,
Françoise BrunVézinet,
Sophie Matheron,
Rémi Cheynier,
Vincent Vieillard
Publication year - 2019
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002061
Subject(s) - flow cytometry , immune system , cytolysis , immunology , biology , downregulation and upregulation , innate immune system , effector , receptor , virology , cytotoxic t cell , in vitro , gene , genetics
HIV-1 and HIV-2 differ notably in their epidemiology, with worldwide HIV-1 spread and HIV-2 mainly confined to West Africa. Natural killer (NK) cells are critical antiviral effectors of the immune system; however, limited information is available about these innate effector cells during HIV-2 infection.