Open AccessMetabolic pathway activation distinguishes transcriptional signatures of CD8+ T cells from HIV-1 elite controllers
Author(s) -
Fatema Z. Chowdhury,
Zhengyu Ouyang,
María J. Buzón,
Bruce D. Walker,
Mathias Lichterfeld,
Xu G. Yu
Publication year - 2018
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002007
Subject(s) - biology , immune system , cd8 , pi3k/akt/mtor pathway , gene expression profiling , microarray , microarray analysis techniques , transcriptional regulation , peripheral blood mononuclear cell , cytotoxic t cell , immunology , gene expression , cancer research , microbiology and biotechnology , gene , signal transduction , genetics , in vitro
Elite controllers, defined as persons maintaining undetectable levels of HIV-1 replication in the absence of antiretroviral therapy, represent living evidence that sustained, natural control of HIV-1 is possible, at least in relatively rare instances. Understanding the complex immunologic and virologic characteristics of these specific patients holds promise for inducing drug-free control of HIV-1 in broader populations of HIV-1 infected patients.