Open AccessIncrease in HSV shedding at initiation of antiretroviral therapy and decrease in shedding over time on antiretroviral therapy in HIV and HSV-2 infected persons
Author(s) -
Emily Ford,
Amalia Magaret,
W Cedric,
Stacy Selke,
Steve Kuntz,
Lawrence Corey,
Anna Wald
Publication year - 2018
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002002
Subject(s) - viral shedding , medicine , discontinuation , antiretroviral therapy , herpes simplex virus , sex organ , viral load , herpes genitalis , hsl and hsv , immunology , human immunodeficiency virus (hiv) , virus , genital herpes , biology , genetics
HIV-infected persons with chronic herpesvirus infections may experience paradoxical worsening after initiation of antiretroviral therapy (ART), but the impact of longer term ART is unclear. We evaluated the relationships between genital herpes simplex virus (HSV) shedding and ART initiation and time on therapy in HIV and HSV-2-infected persons.