Open AccessmTOR signaling mediates effects of common gamma-chain cytokines on T cell proliferation and exhaustion
Author(s) -
Harry E. Taylor,
Nina Calantone,
Richard T D'Aquila
Publication year - 2018
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000001997
Subject(s) - pi3k/akt/mtor pathway , immune system , immunology , biology , cell growth , cytokine , t cell , sirolimus , signal transduction , microbiology and biotechnology , cancer research , genetics , biochemistry
: Chronic elevation of plasma cytokines is a key feature of HIV infection. The physiological consequences of this response to infection and its role in HIV persistence are not fully understood. Here, we show that common gamma chain (γc)-cytokines induce both proliferation and expression of T cell exhaustion markers in a mammalian target of rapamycin (mTOR)-dependent fashion, suggesting a possible therapeutic target that, if inhibited, could diminish HIV reservoir expansion, persistence, and resistance to immune surveillance.