Open AccessMicroglial activation is inversely associated with cognition in individuals living with HIV on effective antiretroviral therapy
Author(s) -
Leah H. Rubin,
Ned Sacktor,
Jason Creighton,
Yong Du,
Christopher J. Endres,
Martin G. Pomper,
Jennifer M. Coughlin
Publication year - 2018
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000001858
Subject(s) - cognition , neuroscience , hippocampus , verbal memory , translocator protein , working memory , cortex (anatomy) , temporal cortex , neuropsychology , effects of sleep deprivation on cognitive performance , executive functions , medicine , psychology , microglia , immunology , inflammation
Despite viral suppression, HIV-associated cognitive impairment persists and may be partially due to persistent immune signalling by cells of the myeloid-lineage. Here, we aimed to understand the contribution of activated microglia located in vulnerable brain regions (e.g. frontal, subcortical) of HIV-infected, virally suppressed (HIV+VS) individuals in relation to cognitive and motor function.