Open AccessAnti-HIV IgM protects against mucosal SHIV transmission
Author(s) -
Siqi Gong,
Khamis Tomusange,
Viraj Kulkarni,
Opeyemi S. Adeniji,
Samir K. Lakhashe,
Dinesh Hariraju,
Amanda Strickland,
Elizabeth Plake,
Patrice A. Frost,
Sarah J. Ratcliffe,
Liping Wang,
Eileen M. Lafer,
Ruth M. Ruprecht
Publication year - 2018
Publication title -
aids
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000001857
Subject(s) - virology , transmission (telecommunications) , immunology , human immunodeficiency virus (hiv) , medicine , computer science , telecommunications
Worldwide, most new HIV infections occur through mucosal exposure. Immunoglobulin M (IgM) is the first antibody class generated in response to infectious agents; IgM is present in the systemic circulation and in mucosal fluids as secretory IgM. We sought to investigate for the first time the role of IgM in preventing AIDS virus acquisition in vivo.