Open AccessProgressive lentivirus infection induces natural killer cell receptor-expressing B cells in the gastrointestinal tract
Author(s) -
Cordelia Manickam,
C Nwanze,
Daniela Ram,
Shah Sh,
Scott Smith,
Rhianna Jones,
Brady Hueber,
Kyle Kroll,
Varner,
Paul Goepfert,
Stéphanie Jost,
R. Keith Reeves
Publication year - 2018
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000001855
Subject(s) - biology , immunology , simian immunodeficiency virus , cd8 , lentivirus , virology , population , antibody , cytotoxic t cell , immune system , interleukin 7 receptor , b cell , flow cytometry , t cell , virus , in vitro , medicine , genetics , il 2 receptor , viral disease , environmental health
Recently, a seemingly novel innate immune cell subset bearing features of natural killer and B cells was identified in mice. So-called NKB cells appear as first responders to infections, but whether this cell population is truly novel or is in fact a subpopulation of B cells and exists in higher primates remains unclear. The objective of this study was to identify NKB cells in primates and study the impact of HIV/SIV infections.