Open AccessDysregulation of apoptosis and autophagy gene expression in peripheral blood mononuclear cells of efficiently treated HIV-infected patients
Author(s) -
A. Serrano,
Saïd Haddad,
Frédéric Le Moal,
Thiérry Prazuck,
Éric Legac,
Chloé Robin,
Frédéric van den Brûle,
Stéphane Charpentier,
Thierry Normand,
Alain Legrand,
Laurent Hocqueloux,
Lucile Mollet
Publication year - 2018
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000001851
Subject(s) - becn1 , peripheral blood mononuclear cell , cart , autophagy , atg8 , mcl1 , apoptosis , biology , immunology , gene , medicine , virology , downregulation and upregulation , in vitro , genetics , mechanical engineering , engineering
We measure the transcript levels of the proapoptotic GALIG, antiapoptotic MCL1 genes and those of the autophagy genes BECN1, MAP1LC3B, ATG9a, P62/SQSTM1, GABARAP, GABARAPL1 and GABARAPL2 to define if mRNA alteration can characterize HIV-infected patients effectively treated with combined antiretroviral therapy (cART).