Open AccessVagal dysfunction and small intestinal bacterial overgrowth
Author(s) -
Jessica RobinsonPapp,
Alexandra Nmashie,
Elizabeth Pedowitz,
Emma K. T. Benn,
Mary Catherine George,
Sandeep Sharma,
Jacinta Murray,
Josef Macháč,
Sherif Heiba,
Saurabh Mehandru,
Seunghee KimSchulze,
Allison Navis,
Isabel Elicer,
Susan Morgello
Publication year - 2018
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000001802
Subject(s) - small intestinal bacterial overgrowth , medicine , gastric emptying , inflammation , gastroenterology , immunology , cytokine , gastroparesis , breath test , helicobacter pylori , irritable bowel syndrome , stomach
Chronic inflammation in HIV-infected individuals drives disease progression and the development of comorbidities, despite viral suppression with combined antiretroviral therapy. Here, we sought evidence that vagal dysfunction, which occurs commonly as part of HIV-associated autonomic neuropathy, could exacerbate inflammation through gastrointestinal dysmotility, small intestinal bacterial overgrowth (SIBO), and alterations in patterns of soluble immune mediators.