Open AccessRole of toll-like receptor 4 Asp299Gly polymorphism in the development of cardiovascular diseases in HIV-infected patients
Author(s) -
Laura Tarancón-Díez,
Rebeca S. de Pablo-Bernal,
José Luís Jiménez,
Ana Isabel Álvarez-Ríos,
Miguel Genebat,
Isaac RosadoSánchez,
María Ángeles MuñozFernández,
Ezequiel RuizMateos,
Manuel Leal
Publication year - 2018
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000001797
Subject(s) - medicine , odds ratio , single nucleotide polymorphism , proinflammatory cytokine , snp , immunology , diabetes mellitus , gastroenterology , genotype , biology , inflammation , endocrinology , gene , biochemistry
Cardiovascular diseases (CVDs) are one of the main causes of morbimortality in HIV-infected patients on suppressive antiretroviral therapy. The objective of this work was to evaluate the role of single nucleotide polymorphisms (SNPs) in lipopolysaccharide (LPS) Toll-like receptor 4 (TLR4) and CVDs occurrence in HIV-infected patients. Additionally, the functional consequences of carrying these SNPs were analyzed.