Open AccessHIV-infected cannabis users have lower circulating CD16+ monocytes and IFN-γ-inducible protein 10 levels compared with nonusing HIV patients
Author(s) -
Michael D. Rizzo,
R. J. Crawford,
Joseph E. Henriquez,
Yasser A. Aldhamen,
Peter Gulick,
Andrea Amalfitano,
Norbert E. Kaminski
Publication year - 2018
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000001704
Subject(s) - cd16 , monocyte , flow cytometry , immunology , peripheral blood mononuclear cell , in vitro , cd14 , medicine , cannabis , biology , immune system , cd8 , cd3 , biochemistry , psychiatry
Chronic immune activation and elevated numbers of circulating activated monocytes (CD16) are implicated in HIV-associated neuroinflammation. The objective was to compare the level of circulating CD16 monocytes and IFN-γ-inducible protein 10 (IP-10) between HIV-infected cannabis users (HIV+MJ+) and noncannabis users (HIV+MJ-) and determine whether in-vitro Δ-Tetrahydrocannabinol (THC), a constituent of cannabis, affected CD16 expression as well as IP-10 production by monocytes.