Open AccessPlacental transfer of elvitegravir and cobicistat in an ex-vivo human cotyledon double perfusion model
Author(s) -
Valentine FaureBardon,
Laurent Mandelbrot,
Dominique Duro,
Chloé Dussaux,
Minh Patrick Lê,
Gilles Peytavin
Publication year - 2018
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000001681
Subject(s) - elvitegravir , cobicistat , pharmacology , ex vivo , pharmacokinetics , chemistry , andrology , in vivo , medicine , biology , immunology , viral load , human immunodeficiency virus (hiv) , antiretroviral therapy , microbiology and biotechnology
To determine the transplacental pharmacokinetics of the HIV integrase strand transfer inhibitor elvitegravir and of cobicistat, a cytochrome P450 inhibitor used as a pharmacoenhancer in antiretroviral therapy.