Open AccessPotency of HIV-2-specific antibodies increase in direct association with loss of memory B cells
Author(s) -
Cheila Rocha,
José Duarte,
Pedro Borrego,
Rita Calado,
José Maria Marcelino,
Rita Tendeiro,
Emília Valadas,
Ana E. Sousa,
Nuno Taveira
Publication year - 2017
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000001661
Subject(s) - viremia , antibody , potency , virology , immunology , memory b cell , neutralizing antibody , biology , human immunodeficiency virus (hiv) , b cell , in vitro , biochemistry
: Potent HIV-neutralizing antibodies are critical for vaccination and viral reservoir control. High levels of neutralizing antibodies characterize HIV-2 infection, a naturally occurring model of attenuated HIV disease with low-to-undectable viremia. We found that HIV-2-specific antibody potency increased in direct association with the loss of both switched and unswitched memory B cells in untreated HIV-2 infection. Thus, HIV antibody affinity maturation is linked to memory B-cell exhaustion even in reduced viremia settings.