Open AccessDysregulated B-cell TLR2 expression and elevated regulatory B-cell frequency precede the diagnosis of AIDS-related non-Hodgkin lymphoma
Author(s) -
Basile Siewe,
Joey Pham,
Mardge H. Cohen,
Nancy A. Hessol,
Alexandra Levine,
Otoniel Martı́nez-Maza,
Alan Landay
Publication year - 2015
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000000687
Subject(s) - germinal center , tlr2 , b cell , immunology , lymphoma , cxcr5 , medicine , biology , immune system , antibody , innate immune system
In antiretroviral therapy (ART)-treated patients, to determine if AIDS-related non-Hodgkin lymphoma (AIDS-NHL) is preceded by: elevated frequency of potentially malignant abnormal activated/germinal center-like B cells, elevated serum prevalence of B-cell stimulatory Toll-like receptor (TLR) ligands resulting from HIV infection-associated microbial translocation, dysregulated B-cell TLR expression/signaling, and perturbations in the frequency of immunoregulatory cells.