Open AccessHuman papilloma virus vaccination induces strong human papilloma virus specific cell-mediated immune responses in HIV-infected adolescents and young adults
Author(s) -
Veronica Rai,
Vania Giacomet,
Francesca Penagini,
Valentina Fabiano,
Francesca Calascibetta,
Chiara Mameli,
Stefania Pisanelli,
Gian Vincenzo Zuccotti,
Mario Clerici,
Daria Trabattoni
Publication year - 2015
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000000597
Subject(s) - granzyme b , immunology , immune system , cd8 , virology , virus , interferon gamma , vaccination , elispot , perforin , cellular immunity , cytotoxic t cell , biology , medicine , biochemistry , in vitro
The ability of a quadrivalent human papilloma virus (HPV)-16/18/6/11 virus-like particles vaccine (Gardasil) to elicit HPV-specific cell-mediated immune responses was evaluated in antiretroviral therapy (ART)-treated HIV-infected young adults. Results showed that, after three doses of vaccine, central memory and effector memory CD4(+) and CD8(+) T lymphocytes, as well as HPV-specific interleukin (IL)2(+)/CD4(+), interferon-gamma (IFN-γ(+))/CD4(+), IFN-γ(+)/CD8(+) and tumour necrosis factor-alpha (TNF-α)(+)/CD8(+) T lymphocytes and Perforin and Granzyme B secreting CD8(+) T lymphocytes were significantly increased. Notably, results obtained in HIV-infected patients were comparable to those seen in HIV-uninfected age-matched healthy controls.