Open AccessRenal epithelial cells produce and spread HIV-1 via T-cell contact
Author(s) -
Maria Di Blasi,
Bala S. Balakumaran,
Ping Chen,
Donatella Negri,
Andrea Cara,
Benjamin Chen,
Mary E. Klotman
Publication year - 2014
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000000398
Subject(s) - human immunodeficiency virus (hiv) , medicine , virology
Increasing evidence supports the role of the kidney as a reservoir for HIV-1. In-vitro co-cultivation of HIV-infected T cells with renal tubule epithelial (RTE) cells results in virus transfer to the latter, whereas cell-free virus infection is inefficient. We further characterized the fate of HIV-1 after it is internalized in renal epithelial cells.