Open AccessSoluble Toll-like receptor 2 is significantly elevated in HIV-1 infected breast milk and inhibits HIV-1 induced cellular activation, inflammation and infection
Author(s) -
Bethany M. Henrick,
XiaoDan Yao,
Anna G. Drannik,
Alash’le Abimiku,
Kenneth L. Rosenthal
Publication year - 2014
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000000381
Subject(s) - tlr2 , proinflammatory cytokine , breast milk , gp41 , immunology , chemokine , inflammation , receptor , biology , toll like receptor , innate immune system , medicine , immune system , tlr4 , antigen , biochemistry , epitope
We previously demonstrated that immunodepletion of soluble Toll-like receptor 2 (sTLR2) from human breast milk significantly increased HIV infection in vitro. The aims of this study were to characterize sTLR2 levels in breast milk from HIV-infected and uninfected women, and identify a mechanism by which sTLR2 inhibits HIV-induced cellular activation and infection.