Open AccessContinuous Monitoring Detected Respiratory Depressive Episodes in Proximity to Adverse Respiratory Events During the PRODIGY Trial
Author(s) -
Jennifer J. Kor,
Juraj Šprung,
Ashish K. Khanna,
Toby N. Weingarten
Publication year - 2022
Publication title -
journal of patient safety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.546
H-Index - 34
eISSN - 1549-8425
pISSN - 1549-8417
DOI - 10.1097/pts.0000000000001003
Subject(s) - capnography , medicine , pulse oximetry , anesthesia , hypoxemia , respiratory monitoring , adverse effect , apnea , respiratory system , cardiology
The PRediction of Opioid-induced respiratory Depression In patients monitored by capnoGraphY (PRODIGY) trial was a multicenter prospective trial conducted to develop a risk prediction score for opioid-induced respiratory depressive (OIRD) episodes. Several subjects in the PRODIGY trial developed critical respiratory depressive events, which were qualified as reportable adverse events (AEs). In this study, we determine whether those patients also had an episode of OIRD as detected by continuous capnography and pulse oximetry leading up to the critical clinical event.