Open AccessAssociation Among Glucocorticoid Receptor Sensitivity, Fatigue, and Inflammation in Patients With Head and Neck Cancer
Author(s) -
Canhua Xiao,
Ronald C. Eldridge,
Jonathan J. Beitler,
Kristin Higgins,
Cynthia E Chico,
Jennifer C. Felger,
Evanthia C. Wommack,
Tish Knobf,
Nabil F. Saba,
Dong M. Shin,
Deborah Watkins Bruner,
Andrew H. Miller
Publication year - 2020
Publication title -
psychosomatic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.62
H-Index - 187
eISSN - 1534-7796
pISSN - 0033-3174
DOI - 10.1097/psy.0000000000000816
Subject(s) - inflammation , medicine , glucocorticoid receptor , tumor necrosis factor alpha , head and neck cancer , cancer , glucocorticoid , oncology , dexamethasone , radiation therapy , interleukin 6 , gastroenterology , endocrinology
Fatigued cancer patients often have high peripheral inflammation; however, the biological mechanisms of this association remain unclear. We examined whether decreased sensitivity of immune cells to the anti-inflammatory effects of glucocorticoids may contribute to inflammation and fatigue in head and neck cancer (HNC) patients during treatment.