Open AccessThe Role of Hippocampal Functional Connectivity on Multisystem Subclinical Abnormalities in Schizophrenia
Author(s) -
Stephanie Hare,
Joshua Chiappelli,
Anya Savransky,
Bhim M. Adhikari,
Krista Wisner,
Mark D. Kvarta,
Eric L. Goldwaser,
Xiaoming Du,
Shuo Chen,
Laura M. Rowland,
Peter Kochunov,
L. Elliot Hong
Publication year - 2020
Publication title -
psychosomatic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.62
H-Index - 187
eISSN - 1534-7796
pISSN - 0033-3174
DOI - 10.1097/psy.0000000000000813
Subject(s) - hippocampal formation , allostatic load , schizophrenia (object oriented programming) , hippocampus , psychology , resting state fmri , fractional anisotropy , neuroscience , fornix , psychosis , functional magnetic resonance imaging , population , medicine , psychiatry , magnetic resonance imaging , white matter , environmental health , radiology
Schizophrenia is associated with excess medical mortality: patients have an average life expectancy one to two decades shorter than the general population. This study investigates the relationship between aberrant hippocampal resting-state functional connectivity in schizophrenia and cumulative subclinical effects of chronic stress on metabolic, cardiovascular, and immune function using the allostatic load index.