Open AccessIntraoperative Stromal Vascular Fraction Therapy Improves Histomorphometric and Vascular Outcomes in Irradiated Mandibular Fracture Repair
Author(s) -
Kevin M. Urlaub,
Kavitha Ranganathan,
Jeremy V. Lynn,
Alexandra O. Luby,
Lauren N. Patrick,
Noah S. Nelson,
Alexis Donneys,
Steven R. Buchman
Publication year - 2021
Publication title -
plastic and reconstructive surgery/psef cd journals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.841
H-Index - 179
eISSN - 1076-5751
pISSN - 0032-1052
DOI - 10.1097/prs.0000000000007781
Subject(s) - medicine , stromal cell , stromal vascular fraction , bone healing , vascularity , osteotomy , surgery , pathology
Cell-based treatments have demonstrated the capacity to enhance reconstructive outcomes in recent decades but are hindered in clinical utility by regulatory hurdles surrounding cell culture. This investigation examines the ability of a noncultured stromal vascular fraction derived from lipoaspirate to enhance bone healing during fracture repair to further the development of translatable cell therapies that may improve outcomes in irradiated reconstruction.