Open AccessThe Utility of Early Tongue Reduction Surgery for Macroglossia in Beckwith-Wiedemann Syndrome
Author(s) -
Jennifer L. Cohen,
Christopher M. Cielo,
Jonida Kupa,
Kelly A. Duffy,
Evan R Hathaway,
Jennifer M. Kalish,
Jesse A. Taylor
Publication year - 2020
Publication title -
plastic and reconstructive surgery/psef cd journals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.841
H-Index - 179
eISSN - 1076-5751
pISSN - 0032-1052
DOI - 10.1097/prs.0000000000006673
Subject(s) - medicine , macroglossia , beckwith–wiedemann syndrome , obstructive sleep apnea , tongue , polysomnography , glossectomy , interquartile range , uvulopalatopharyngoplasty , surgery , apnea , pediatrics , anesthesia , biochemistry , gene expression , chemistry , pathology , dna methylation , gene
Macroglossia, a cardinal feature of the (epi)genetic disorder Beckwith-Wiedemann syndrome, is associated with obstructive sleep apnea, speech and/or feeding difficulties, and dental or jaw malalignment. These sequelae may be treated and/or prevented with tongue reduction surgery; the authors sought to determine whether certain Beckwith-Wiedemann syndrome patients may benefit from early surgical intervention before age 12 months.