Open AccessNoncontact Phased-Array Ultrasound Facilitates Acute Wound Healing in Mice
Author(s) -
Nao Wakabayashi,
Atsushi Sakai,
Hiroya Takada,
Takayuki Hoshi,
Hitomi Sano,
Shizuko Ichinose,
Hidenori Suzuki,
Rei Ogawa
Publication year - 2020
Publication title -
plastic and reconstructive surgery/psef cd journals
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.841
H-Index - 179
eISSN - 1076-5751
pISSN - 0032-1052
DOI - 10.1097/prs.0000000000006481
Subject(s) - medicine , angiogenesis , wound healing , masson's trichrome stain , cd31 , neovascularization , ultrasound , h&e stain , surgery , immunohistochemistry , pathology , radiology
The authors developed a noncontact low-frequency ultrasound device that delivers high-intensity mechanical force based on phased-array technology. It may aid wound healing because it is likely to be associated with lower risks of infection and heat-induced pain compared with conventional ultrasound methods. The authors hypothesized that the microdeformation it induces accelerates wound epithelialization. Its effects on key wound-healing processes (angiogenesis, collagen accumulation, and angiogenesis-related gene transcription) were also examined.