Open AccessDeferoxamine Preconditioning of Irradiated Tissue Improves Perfusion and Fat Graft Retention
Author(s) -
John Flacco,
Natalie N. Chung,
Charles P. Blackshear,
Dre Irizarry,
Arash Momeni,
Gordon K. Lee,
Dung Nguyen,
Geoffrey C. Gurtner,
Michael T. Longaker,
Derrick C. Wan
Publication year - 2018
Publication title -
plastic and reconstructive surgery/psef cd journals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.841
H-Index - 179
eISSN - 1076-5751
pISSN - 0032-1052
DOI - 10.1097/prs.0000000000004167
Subject(s) - deferoxamine , medicine , perfusion , surgery , urology
Radiation therapy is a mainstay in the treatment of many malignancies, but collateral damage to surrounding tissue, with resultant hypovascularity, fibrosis, and atrophy, can be difficult to reconstruct. Fat grafting has been shown to improve the quality of irradiated skin, but volume retention of the graft is significantly decreased. Deferoxamine is a U.S. Food and Drug Administration-approved iron-chelating medication for acute iron intoxication and chronic iron overload that has also been shown to increase angiogenesis. The present study evaluates the effects of deferoxamine treatment on irradiated skin and subsequent fat graft volume retention.