Open AccessRole of hyperpolarization-activated cyclic nucleotide-gated ion channels in neuropathic pain: a proof-of-concept study of ivabradine in patients with chronic peripheral neuropathic pain
Author(s) -
Shan A Bernard Healey,
Ingrid Scholtes,
Mark Abrahams,
Peter A. McNaughton,
David Me,
Michael C. Lee
Publication year - 2021
Publication title -
pain reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.113
H-Index - 15
ISSN - 2471-2531
DOI - 10.1097/pr9.0000000000000967
Subject(s) - ivabradine , neuropathic pain , medicine , anesthesia , chronic pain , gabapentin , heart rate , peripheral neuropathy , bradycardia , cardiology , endocrinology , diabetes mellitus , physical therapy , blood pressure , alternative medicine , pathology
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channel receptors mediate neuropathic pain in preclinical models. Here, exploratory analysis reveals a dose-dependent reduction in pain with HCN blockade in patients with neuropathic pain.